SYRE
Price
$32.94
Change
-$0.11 (-0.33%)
Updated
Dec 26 closing price
Capitalization
2.56B
61 days until earnings call
Intraday BUY SELL Signals
ZBIO
Price
$42.49
Change
-$0.68 (-1.58%)
Updated
Dec 26 closing price
Capitalization
2.28B
60 days until earnings call
Intraday BUY SELL Signals
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SYRE vs ZBIO

Header iconSYRE vs ZBIO Comparison
Open Charts SYRE vs ZBIOBanner chart's image
Spyre Therapeutics
Price$32.94
Change-$0.11 (-0.33%)
Volume$307.91K
Capitalization2.56B
Zenas Biopharma
Price$42.49
Change-$0.68 (-1.58%)
Volume$134.33K
Capitalization2.28B
SYRE vs ZBIO Comparison Chart in %
SYRE
Daily Signal:
Gain/Loss:
ZBIO
Daily Signal:
Gain/Loss:
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VS
SYRE vs. ZBIO commentary
Dec 28, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is SYRE is a Buy and ZBIO is a Buy.

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COMPARISON
Comparison
Dec 28, 2025
Stock price -- (SYRE: $32.94 vs. ZBIO: $42.49)
Brand notoriety: SYRE and ZBIO are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: SYRE: 39% vs. ZBIO: 30%
Market capitalization -- SYRE: $2.56B vs. ZBIO: $2.28B
SYRE [@Biotechnology] is valued at $2.56B. ZBIO’s [@Biotechnology] market capitalization is $2.28B. The market cap for tickers in the [@Biotechnology] industry ranges from $117.45B to $0. The average market capitalization across the [@Biotechnology] industry is $2.21B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

SYRE’s FA Score shows that 0 FA rating(s) are green whileZBIO’s FA Score has 1 green FA rating(s).

  • SYRE’s FA Score: 0 green, 5 red.
  • ZBIO’s FA Score: 1 green, 4 red.
According to our system of comparison, ZBIO is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

SYRE’s TA Score shows that 3 TA indicator(s) are bullish while ZBIO’s TA Score has 5 bullish TA indicator(s).

  • SYRE’s TA Score: 3 bullish, 5 bearish.
  • ZBIO’s TA Score: 5 bullish, 3 bearish.
According to our system of comparison, ZBIO is a better buy in the short-term than SYRE.

Price Growth

SYRE (@Biotechnology) experienced а -1.38% price change this week, while ZBIO (@Biotechnology) price change was +17.54% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +0.36%. For the same industry, the average monthly price growth was +0.27%, and the average quarterly price growth was +54.56%.

Reported Earning Dates

SYRE is expected to report earnings on Feb 26, 2026.

ZBIO is expected to report earnings on Feb 25, 2026.

Industries' Descriptions

@Biotechnology (+0.36% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
SYRE($2.56B) has a higher market cap than ZBIO($2.28B). ZBIO has higher P/E ratio than SYRE: ZBIO (3.11) vs SYRE (1.72). ZBIO YTD gains are higher at: 418.803 vs. SYRE (41.495). ZBIO has higher annual earnings (EBITDA): -195.62M vs. SYRE (-223.64M). SYRE has more cash in the bank: 486M vs. ZBIO (291M). SYRE has less debt than ZBIO: SYRE (0) vs ZBIO (798K). ZBIO has higher revenues than SYRE: ZBIO (15M) vs SYRE (0).
SYREZBIOSYRE / ZBIO
Capitalization2.56B2.28B112%
EBITDA-223.64M-195.62M114%
Gain YTD41.495418.80310%
P/E Ratio1.723.1155%
Revenue015M-
Total Cash486M291M167%
Total Debt0798K-
FUNDAMENTALS RATINGS
SYRE vs ZBIO: Fundamental Ratings
SYRE
ZBIO
OUTLOOK RATING
1..100
6223
VALUATION
overvalued / fair valued / undervalued
1..100
70
Overvalued
61
Fair valued
PROFIT vs RISK RATING
1..100
100100
SMR RATING
1..100
97100
PRICE GROWTH RATING
1..100
3634
P/E GROWTH RATING
1..100
8027
SEASONALITY SCORE
1..100
5012

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

ZBIO's Valuation (61) in the null industry is in the same range as SYRE (70) in the Pharmaceuticals Major industry. This means that ZBIO’s stock grew similarly to SYRE’s over the last 12 months.

ZBIO's Profit vs Risk Rating (100) in the null industry is in the same range as SYRE (100) in the Pharmaceuticals Major industry. This means that ZBIO’s stock grew similarly to SYRE’s over the last 12 months.

SYRE's SMR Rating (97) in the Pharmaceuticals Major industry is in the same range as ZBIO (100) in the null industry. This means that SYRE’s stock grew similarly to ZBIO’s over the last 12 months.

ZBIO's Price Growth Rating (34) in the null industry is in the same range as SYRE (36) in the Pharmaceuticals Major industry. This means that ZBIO’s stock grew similarly to SYRE’s over the last 12 months.

ZBIO's P/E Growth Rating (27) in the null industry is somewhat better than the same rating for SYRE (80) in the Pharmaceuticals Major industry. This means that ZBIO’s stock grew somewhat faster than SYRE’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
SYREZBIO
RSI
ODDS (%)
Bearish Trend 2 days ago
90%
Bearish Trend 2 days ago
90%
Stochastic
ODDS (%)
Bullish Trend 2 days ago
80%
Bearish Trend 2 days ago
90%
Momentum
ODDS (%)
Bearish Trend 2 days ago
86%
Bullish Trend 2 days ago
90%
MACD
ODDS (%)
Bearish Trend 2 days ago
86%
Bullish Trend 2 days ago
90%
TrendWeek
ODDS (%)
Bearish Trend 2 days ago
87%
Bullish Trend 2 days ago
90%
TrendMonth
ODDS (%)
Bullish Trend 2 days ago
83%
Bullish Trend 2 days ago
90%
Advances
ODDS (%)
Bullish Trend 10 days ago
85%
Bullish Trend 4 days ago
90%
Declines
ODDS (%)
Bearish Trend 2 days ago
90%
Bearish Trend 10 days ago
80%
BollingerBands
ODDS (%)
Bearish Trend 2 days ago
87%
Bullish Trend 2 days ago
83%
Aroon
ODDS (%)
Bullish Trend 2 days ago
86%
Bullish Trend 2 days ago
90%
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SYRE
Daily Signal:
Gain/Loss:
ZBIO
Daily Signal:
Gain/Loss:
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ZBIO and

Correlation & Price change

A.I.dvisor indicates that over the last year, ZBIO has been loosely correlated with IDYA. These tickers have moved in lockstep 50% of the time. This A.I.-generated data suggests there is some statistical probability that if ZBIO jumps, then IDYA could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To ZBIO
1D Price
Change %
ZBIO100%
-1.58%
IDYA - ZBIO
50%
Loosely correlated
-1.35%
RGNX - ZBIO
47%
Loosely correlated
-2.07%
SYRE - ZBIO
47%
Loosely correlated
-0.33%
APGE - ZBIO
46%
Loosely correlated
-0.99%
KURA - ZBIO
45%
Loosely correlated
-3.89%
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