SYRE
Price
$32.20
Change
+$3.80 (+13.38%)
Updated
Dec 3, 04:59 PM (EDT)
Capitalization
2.22B
85 days until earnings call
Intraday BUY SELL Signals
XENE
Price
$44.28
Change
+$1.40 (+3.26%)
Updated
Dec 3, 04:59 PM (EDT)
Capitalization
3.36B
85 days until earnings call
Intraday BUY SELL Signals
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SYRE vs XENE

Header iconSYRE vs XENE Comparison
Open Charts SYRE vs XENEBanner chart's image
Spyre Therapeutics
Price$32.20
Change+$3.80 (+13.38%)
Volume$57.92K
Capitalization2.22B
Xenon Pharmaceuticals
Price$44.28
Change+$1.40 (+3.26%)
Volume$33.69K
Capitalization3.36B
SYRE vs XENE Comparison Chart in %
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VS
SYRE vs. XENE commentary
Dec 04, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is SYRE is a Hold and XENE is a StrongBuy.

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COMPARISON
Comparison
Dec 04, 2025
Stock price -- (SYRE: $28.40 vs. XENE: $42.88)
Brand notoriety: SYRE and XENE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: SYRE: 23% vs. XENE: 53%
Market capitalization -- SYRE: $2.22B vs. XENE: $3.36B
SYRE [@Biotechnology] is valued at $2.22B. XENE’s [@Biotechnology] market capitalization is $3.36B. The market cap for tickers in the [@Biotechnology] industry ranges from $107.98B to $0. The average market capitalization across the [@Biotechnology] industry is $2.19B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

SYRE’s FA Score shows that 0 FA rating(s) are green whileXENE’s FA Score has 2 green FA rating(s).

  • SYRE’s FA Score: 0 green, 5 red.
  • XENE’s FA Score: 2 green, 3 red.
According to our system of comparison, XENE is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

SYRE’s TA Score shows that 4 TA indicator(s) are bullish while XENE’s TA Score has 5 bullish TA indicator(s).

  • SYRE’s TA Score: 4 bullish, 4 bearish.
  • XENE’s TA Score: 5 bullish, 5 bearish.
According to our system of comparison, both SYRE and XENE are a good buy in the short-term.

Price Growth

SYRE (@Biotechnology) experienced а -2.74% price change this week, while XENE (@Biotechnology) price change was -2.41% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +0.32%. For the same industry, the average monthly price growth was +1.23%, and the average quarterly price growth was +54.93%.

Reported Earning Dates

SYRE is expected to report earnings on Feb 26, 2026.

XENE is expected to report earnings on Feb 26, 2026.

Industries' Descriptions

@Biotechnology (+0.32% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
XENE($3.36B) has a higher market cap than SYRE($2.22B). SYRE YTD gains are higher at: 21.993 vs. XENE (9.388). SYRE has higher annual earnings (EBITDA): -222.15M vs. XENE (-315.5M). SYRE has more cash in the bank: 527M vs. XENE (488M). SYRE has less debt than XENE: SYRE (0) vs XENE (8.72M). XENE has higher revenues than SYRE: XENE (7.5M) vs SYRE (0).
SYREXENESYRE / XENE
Capitalization2.22B3.36B66%
EBITDA-222.15M-315.5M70%
Gain YTD21.9939.388234%
P/E Ratio1.72N/A-
Revenue07.5M-
Total Cash527M488M108%
Total Debt08.72M-
FUNDAMENTALS RATINGS
SYRE vs XENE: Fundamental Ratings
SYRE
XENE
OUTLOOK RATING
1..100
5050
VALUATION
overvalued / fair valued / undervalued
1..100
69
Overvalued
75
Overvalued
PROFIT vs RISK RATING
1..100
10030
SMR RATING
1..100
9796
PRICE GROWTH RATING
1..100
3642
P/E GROWTH RATING
1..100
745
SEASONALITY SCORE
1..100
n/a50

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

SYRE's Valuation (69) in the Pharmaceuticals Major industry is in the same range as XENE (75) in the Biotechnology industry. This means that SYRE’s stock grew similarly to XENE’s over the last 12 months.

XENE's Profit vs Risk Rating (30) in the Biotechnology industry is significantly better than the same rating for SYRE (100) in the Pharmaceuticals Major industry. This means that XENE’s stock grew significantly faster than SYRE’s over the last 12 months.

XENE's SMR Rating (96) in the Biotechnology industry is in the same range as SYRE (97) in the Pharmaceuticals Major industry. This means that XENE’s stock grew similarly to SYRE’s over the last 12 months.

SYRE's Price Growth Rating (36) in the Pharmaceuticals Major industry is in the same range as XENE (42) in the Biotechnology industry. This means that SYRE’s stock grew similarly to XENE’s over the last 12 months.

XENE's P/E Growth Rating (5) in the Biotechnology industry is significantly better than the same rating for SYRE (74) in the Pharmaceuticals Major industry. This means that XENE’s stock grew significantly faster than SYRE’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
SYREXENE
RSI
ODDS (%)
Bearish Trend 6 days ago
90%
Bearish Trend 6 days ago
86%
Stochastic
ODDS (%)
Bearish Trend 6 days ago
88%
Bearish Trend 6 days ago
84%
Momentum
ODDS (%)
Bullish Trend 6 days ago
87%
Bullish Trend 6 days ago
73%
MACD
ODDS (%)
Bullish Trend 6 days ago
80%
Bullish Trend 6 days ago
79%
TrendWeek
ODDS (%)
Bullish Trend 6 days ago
83%
Bullish Trend 6 days ago
75%
TrendMonth
ODDS (%)
Bullish Trend 6 days ago
83%
Bullish Trend 6 days ago
74%
Advances
ODDS (%)
Bullish Trend 6 days ago
85%
Bullish Trend 6 days ago
72%
Declines
ODDS (%)
Bearish Trend 28 days ago
90%
Bearish Trend 27 days ago
70%
BollingerBands
ODDS (%)
Bearish Trend 6 days ago
90%
Bearish Trend 6 days ago
76%
Aroon
ODDS (%)
Bullish Trend 6 days ago
82%
Bearish Trend 6 days ago
79%
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SYRE
Daily Signal:
Gain/Loss:
XENE
Daily Signal:
Gain/Loss:
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SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with APGE. These tickers have moved in lockstep 58% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then APGE could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
-0.91%
APGE - SYRE
58%
Loosely correlated
+0.20%
CGON - SYRE
58%
Loosely correlated
-4.35%
RGNX - SYRE
57%
Loosely correlated
-3.10%
IDYA - SYRE
57%
Loosely correlated
-1.75%
ORKA - SYRE
56%
Loosely correlated
+0.56%
More

XENE and

Correlation & Price change

A.I.dvisor indicates that over the last year, XENE has been loosely correlated with IDYA. These tickers have moved in lockstep 58% of the time. This A.I.-generated data suggests there is some statistical probability that if XENE jumps, then IDYA could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To XENE
1D Price
Change %
XENE100%
-1.45%
IDYA - XENE
58%
Loosely correlated
-1.75%
NUVL - XENE
58%
Loosely correlated
-1.37%
NRIX - XENE
52%
Loosely correlated
-3.31%
DNLI - XENE
51%
Loosely correlated
-1.71%
SYRE - XENE
51%
Loosely correlated
-0.91%
More