SYRE
Price
$16.35
Change
+$0.06 (+0.37%)
Updated
Jul 21 closing price
Capitalization
986.78M
9 days until earnings call
VYNE
Price
$1.21
Change
+$0.05 (+4.31%)
Updated
Jul 21 closing price
Capitalization
20.16M
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SYRE vs VYNE

Header iconSYRE vs VYNE Comparison
Open Charts SYRE vs VYNEBanner chart's image
Spyre Therapeutics
Price$16.35
Change+$0.06 (+0.37%)
Volume$513.56K
Capitalization986.78M
VYNE Therapeutics
Price$1.21
Change+$0.05 (+4.31%)
Volume$1.08M
Capitalization20.16M
SYRE vs VYNE Comparison Chart in %
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SYRE
Daily Signalchanged days ago
Gain/Loss if bought
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VYNE
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE vs. VYNE commentary
Jul 22, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is SYRE is a Hold and VYNE is a Hold.

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COMPARISON
Comparison
Jul 22, 2025
Stock price -- (SYRE: $16.35 vs. VYNE: $1.21)
Brand notoriety: SYRE and VYNE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: SYRE: 93% vs. VYNE: 133%
Market capitalization -- SYRE: $986.78M vs. VYNE: $20.16M
SYRE [@Biotechnology] is valued at $986.78M. VYNE’s [@Biotechnology] market capitalization is $20.16M. The market cap for tickers in the [@Biotechnology] industry ranges from $286.69B to $0. The average market capitalization across the [@Biotechnology] industry is $2.44B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

SYRE’s FA Score shows that 0 FA rating(s) are green whileVYNE’s FA Score has 1 green FA rating(s).

  • SYRE’s FA Score: 0 green, 5 red.
  • VYNE’s FA Score: 1 green, 4 red.
According to our system of comparison, VYNE is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

SYRE’s TA Score shows that 6 TA indicator(s) are bullish while VYNE’s TA Score has 3 bullish TA indicator(s).

  • SYRE’s TA Score: 6 bullish, 3 bearish.
  • VYNE’s TA Score: 3 bullish, 7 bearish.
According to our system of comparison, SYRE is a better buy in the short-term than VYNE.

Price Growth

SYRE (@Biotechnology) experienced а -0.37% price change this week, while VYNE (@Biotechnology) price change was -9.02% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +2.39%. For the same industry, the average monthly price growth was +15.71%, and the average quarterly price growth was +33.77%.

Reported Earning Dates

SYRE is expected to report earnings on Jul 31, 2025.

Industries' Descriptions

@Biotechnology (+2.39% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
SYRE($987M) has a higher market cap than VYNE($20.2M). SYRE has higher P/E ratio than VYNE: SYRE (1.68) vs VYNE (0.71). SYRE YTD gains are higher at: -29.768 vs. VYNE (-63.881). VYNE has higher annual earnings (EBITDA): -45.44M vs. SYRE (-214.36M). SYRE has more cash in the bank: 565M vs. VYNE (50.3M). SYRE has less debt than VYNE: SYRE (0) vs VYNE (63K). VYNE has higher revenues than SYRE: VYNE (605K) vs SYRE (0).
SYREVYNESYRE / VYNE
Capitalization987M20.2M4,886%
EBITDA-214.36M-45.44M472%
Gain YTD-29.768-63.88147%
P/E Ratio1.680.71238%
Revenue0605K-
Total Cash565M50.3M1,123%
Total Debt063K-
FUNDAMENTALS RATINGS
SYRE vs VYNE: Fundamental Ratings
SYRE
VYNE
OUTLOOK RATING
1..100
5050
VALUATION
overvalued / fair valued / undervalued
1..100
74
Overvalued
34
Fair valued
PROFIT vs RISK RATING
1..100
100100
SMR RATING
1..100
9898
PRICE GROWTH RATING
1..100
5765
P/E GROWTH RATING
1..100
821
SEASONALITY SCORE
1..100
n/an/a

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

VYNE's Valuation (34) in the Pharmaceuticals Major industry is somewhat better than the same rating for SYRE (74). This means that VYNE’s stock grew somewhat faster than SYRE’s over the last 12 months.

VYNE's Profit vs Risk Rating (100) in the Pharmaceuticals Major industry is in the same range as SYRE (100). This means that VYNE’s stock grew similarly to SYRE’s over the last 12 months.

VYNE's SMR Rating (98) in the Pharmaceuticals Major industry is in the same range as SYRE (98). This means that VYNE’s stock grew similarly to SYRE’s over the last 12 months.

SYRE's Price Growth Rating (57) in the Pharmaceuticals Major industry is in the same range as VYNE (65). This means that SYRE’s stock grew similarly to VYNE’s over the last 12 months.

VYNE's P/E Growth Rating (1) in the Pharmaceuticals Major industry is significantly better than the same rating for SYRE (82). This means that VYNE’s stock grew significantly faster than SYRE’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
SYREVYNE
RSI
ODDS (%)
Bearish Trend 6 days ago
90%
Bearish Trend 4 days ago
90%
Stochastic
ODDS (%)
Bullish Trend 4 days ago
84%
Bullish Trend 4 days ago
82%
Momentum
ODDS (%)
Bullish Trend 4 days ago
84%
Bearish Trend 4 days ago
82%
MACD
ODDS (%)
Bullish Trend 4 days ago
78%
Bearish Trend 4 days ago
90%
TrendWeek
ODDS (%)
Bullish Trend 4 days ago
84%
Bearish Trend 4 days ago
89%
TrendMonth
ODDS (%)
Bearish Trend 4 days ago
89%
Bullish Trend 4 days ago
76%
Advances
ODDS (%)
Bullish Trend 5 days ago
85%
Bullish Trend 13 days ago
79%
Declines
ODDS (%)
Bearish Trend 11 days ago
89%
Bearish Trend 4 days ago
88%
BollingerBands
ODDS (%)
Bearish Trend 4 days ago
90%
Bearish Trend 4 days ago
90%
Aroon
ODDS (%)
Bullish Trend 4 days ago
84%
Bearish Trend 4 days ago
89%
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SYRE
Daily Signalchanged days ago
Gain/Loss if bought
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VYNE
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with IDYA. These tickers have moved in lockstep 59% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then IDYA could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
+0.37%
IDYA - SYRE
59%
Loosely correlated
+1.02%
BEAM - SYRE
59%
Loosely correlated
+1.35%
CGON - SYRE
59%
Loosely correlated
-5.48%
XNCR - SYRE
56%
Loosely correlated
+1.45%
CRNX - SYRE
55%
Loosely correlated
-0.51%
More

VYNE and

Correlation & Price change

A.I.dvisor indicates that over the last year, VYNE has been loosely correlated with EYPT. These tickers have moved in lockstep 34% of the time. This A.I.-generated data suggests there is some statistical probability that if VYNE jumps, then EYPT could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To VYNE
1D Price
Change %
VYNE100%
+4.31%
EYPT - VYNE
34%
Loosely correlated
+2.33%
SYRE - VYNE
34%
Loosely correlated
+0.37%
GLTO - VYNE
30%
Poorly correlated
+0.23%
ARCT - VYNE
30%
Poorly correlated
+2.15%
NKTR - VYNE
30%
Poorly correlated
-0.60%
More