SYRE
Price
$33.05
Change
-$0.18 (-0.54%)
Updated
Dec 24 closing price
Capitalization
2.56B
63 days until earnings call
Intraday BUY SELL Signals
VRDN
Price
$32.28
Change
+$0.17 (+0.53%)
Updated
Dec 24 closing price
Capitalization
3.08B
70 days until earnings call
Intraday BUY SELL Signals
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SYRE vs VRDN

Header iconSYRE vs VRDN Comparison
Open Charts SYRE vs VRDNBanner chart's image
Spyre Therapeutics
Price$33.05
Change-$0.18 (-0.54%)
Volume$291.96K
Capitalization2.56B
Viridian Therapeutics
Price$32.28
Change+$0.17 (+0.53%)
Volume$403.58K
Capitalization3.08B
SYRE vs VRDN Comparison Chart in %
SYRE
Daily Signal:
Gain/Loss:
VRDN
Daily Signal:
Gain/Loss:
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SYRE vs. VRDN commentary
Dec 25, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is SYRE is a Hold and VRDN is a Hold.

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COMPARISON
Comparison
Dec 25, 2025
Stock price -- (SYRE: $33.05 vs. VRDN: $32.28)
Brand notoriety: SYRE and VRDN are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: SYRE: 37% vs. VRDN: 22%
Market capitalization -- SYRE: $2.56B vs. VRDN: $3.08B
SYRE [@Biotechnology] is valued at $2.56B. VRDN’s [@Biotechnology] market capitalization is $3.08B. The market cap for tickers in the [@Biotechnology] industry ranges from $117.47B to $0. The average market capitalization across the [@Biotechnology] industry is $2.23B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

SYRE’s FA Score shows that 0 FA rating(s) are green whileVRDN’s FA Score has 0 green FA rating(s).

  • SYRE’s FA Score: 0 green, 5 red.
  • VRDN’s FA Score: 0 green, 5 red.
According to our system of comparison, VRDN is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

SYRE’s TA Score shows that 2 TA indicator(s) are bullish while VRDN’s TA Score has 3 bullish TA indicator(s).

  • SYRE’s TA Score: 2 bullish, 6 bearish.
  • VRDN’s TA Score: 3 bullish, 5 bearish.
According to our system of comparison, VRDN is a better buy in the short-term than SYRE.

Price Growth

SYRE (@Biotechnology) experienced а -0.03% price change this week, while VRDN (@Biotechnology) price change was +0.47% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +2.88%. For the same industry, the average monthly price growth was +4.46%, and the average quarterly price growth was +55.39%.

Reported Earning Dates

SYRE is expected to report earnings on Feb 26, 2026.

VRDN is expected to report earnings on Mar 05, 2026.

Industries' Descriptions

@Biotechnology (+2.88% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
VRDN($3.08B) has a higher market cap than SYRE($2.56B). VRDN YTD gains are higher at: 68.388 vs. SYRE (41.967). SYRE has higher annual earnings (EBITDA): -223.64M vs. VRDN (-298.48M). VRDN (491M) and SYRE (486M) have equal amount of cash in the bank . SYRE has less debt than VRDN: SYRE (0) vs VRDN (21.6M). VRDN has higher revenues than SYRE: VRDN (70.8M) vs SYRE (0).
SYREVRDNSYRE / VRDN
Capitalization2.56B3.08B83%
EBITDA-223.64M-298.48M75%
Gain YTD41.96768.38861%
P/E Ratio1.72N/A-
Revenue070.8M-
Total Cash486M491M99%
Total Debt021.6M-
FUNDAMENTALS RATINGS
SYRE vs VRDN: Fundamental Ratings
SYRE
VRDN
OUTLOOK RATING
1..100
6476
VALUATION
overvalued / fair valued / undervalued
1..100
70
Overvalued
52
Fair valued
PROFIT vs RISK RATING
1..100
10062
SMR RATING
1..100
9798
PRICE GROWTH RATING
1..100
3637
P/E GROWTH RATING
1..100
80100
SEASONALITY SCORE
1..100
5050

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

VRDN's Valuation (52) in the Biotechnology industry is in the same range as SYRE (70) in the Pharmaceuticals Major industry. This means that VRDN’s stock grew similarly to SYRE’s over the last 12 months.

VRDN's Profit vs Risk Rating (62) in the Biotechnology industry is somewhat better than the same rating for SYRE (100) in the Pharmaceuticals Major industry. This means that VRDN’s stock grew somewhat faster than SYRE’s over the last 12 months.

SYRE's SMR Rating (97) in the Pharmaceuticals Major industry is in the same range as VRDN (98) in the Biotechnology industry. This means that SYRE’s stock grew similarly to VRDN’s over the last 12 months.

SYRE's Price Growth Rating (36) in the Pharmaceuticals Major industry is in the same range as VRDN (37) in the Biotechnology industry. This means that SYRE’s stock grew similarly to VRDN’s over the last 12 months.

SYRE's P/E Growth Rating (80) in the Pharmaceuticals Major industry is in the same range as VRDN (100) in the Biotechnology industry. This means that SYRE’s stock grew similarly to VRDN’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
SYREVRDN
RSI
ODDS (%)
Bearish Trend 2 days ago
90%
Bearish Trend 2 days ago
83%
Stochastic
ODDS (%)
Bearish Trend 2 days ago
90%
Bullish Trend 2 days ago
74%
Momentum
ODDS (%)
Bearish Trend 2 days ago
84%
Bearish Trend 2 days ago
85%
MACD
ODDS (%)
Bearish Trend 2 days ago
89%
Bearish Trend 2 days ago
78%
TrendWeek
ODDS (%)
Bearish Trend 2 days ago
87%
Bullish Trend 2 days ago
82%
TrendMonth
ODDS (%)
Bullish Trend 2 days ago
83%
Bullish Trend 2 days ago
83%
Advances
ODDS (%)
Bullish Trend 8 days ago
85%
Bullish Trend 4 days ago
81%
Declines
ODDS (%)
Bearish Trend 2 days ago
90%
Bearish Trend 8 days ago
84%
BollingerBands
ODDS (%)
Bearish Trend 2 days ago
87%
Bearish Trend 2 days ago
76%
Aroon
ODDS (%)
Bullish Trend 2 days ago
84%
Bullish Trend 2 days ago
87%
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SYRE
Daily Signal:
Gain/Loss:
VRDN
Daily Signal:
Gain/Loss:
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SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with BEAM. These tickers have moved in lockstep 57% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then BEAM could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
-0.54%
BEAM - SYRE
57%
Loosely correlated
+1.33%
XNCR - SYRE
57%
Loosely correlated
-0.13%
RGNX - SYRE
57%
Loosely correlated
+0.77%
CGON - SYRE
56%
Loosely correlated
+0.22%
APGE - SYRE
56%
Loosely correlated
+1.02%
More

VRDN and

Correlation & Price change

A.I.dvisor indicates that over the last year, VRDN has been loosely correlated with NUVL. These tickers have moved in lockstep 58% of the time. This A.I.-generated data suggests there is some statistical probability that if VRDN jumps, then NUVL could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To VRDN
1D Price
Change %
VRDN100%
+0.53%
NUVL - VRDN
58%
Loosely correlated
+0.89%
XNCR - VRDN
56%
Loosely correlated
-0.13%
CLDX - VRDN
54%
Loosely correlated
+0.94%
SYRE - VRDN
54%
Loosely correlated
-0.54%
RVMD - VRDN
51%
Loosely correlated
+1.15%
More