SPRO
Price
$1.89
Change
-$0.05 (-2.58%)
Updated
Sep 26 closing price
Capitalization
106.36M
50 days until earnings call
XENE
Price
$37.98
Change
+$1.46 (+4.00%)
Updated
Sep 26 closing price
Capitalization
2.93B
38 days until earnings call
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SPRO vs XENE

Header iconSPRO vs XENE Comparison
Open Charts SPRO vs XENEBanner chart's image
Spero Therapeutics
Price$1.89
Change-$0.05 (-2.58%)
Volume$397.5K
Capitalization106.36M
Xenon Pharmaceuticals
Price$37.98
Change+$1.46 (+4.00%)
Volume$680.07K
Capitalization2.93B
SPRO vs XENE Comparison Chart in %
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SPRO
Daily Signalchanged days ago
Gain/Loss if bought
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XENE
Daily Signalchanged days ago
Gain/Loss if bought
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SPRO vs. XENE commentary
Sep 28, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is SPRO is a Hold and XENE is a Buy.

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COMPARISON
Comparison
Sep 28, 2025
Stock price -- (SPRO: $1.89 vs. XENE: $37.98)
Brand notoriety: SPRO and XENE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: SPRO: 78% vs. XENE: 82%
Market capitalization -- SPRO: $106.36M vs. XENE: $2.93B
SPRO [@Biotechnology] is valued at $106.36M. XENE’s [@Biotechnology] market capitalization is $2.93B. The market cap for tickers in the [@Biotechnology] industry ranges from $98.9B to $0. The average market capitalization across the [@Biotechnology] industry is $1.89B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

SPRO’s FA Score shows that 1 FA rating(s) are green whileXENE’s FA Score has 1 green FA rating(s).

  • SPRO’s FA Score: 1 green, 4 red.
  • XENE’s FA Score: 1 green, 4 red.
According to our system of comparison, SPRO is a better buy in the long-term than XENE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

SPRO’s TA Score shows that 3 TA indicator(s) are bullish while XENE’s TA Score has 6 bullish TA indicator(s).

  • SPRO’s TA Score: 3 bullish, 4 bearish.
  • XENE’s TA Score: 6 bullish, 3 bearish.
According to our system of comparison, XENE is a better buy in the short-term than SPRO.

Price Growth

SPRO (@Biotechnology) experienced а -5.50% price change this week, while XENE (@Biotechnology) price change was +2.79% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +4.00%. For the same industry, the average monthly price growth was +9.18%, and the average quarterly price growth was +54.60%.

Reported Earning Dates

SPRO is expected to report earnings on Nov 17, 2025.

XENE is expected to report earnings on Nov 05, 2025.

Industries' Descriptions

@Biotechnology (+4.00% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
XENE($2.93B) has a higher market cap than SPRO($106M). SPRO YTD gains are higher at: 83.495 vs. XENE (-3.112). SPRO has higher annual earnings (EBITDA): -56.36M vs. XENE (-315.5M). XENE has more cash in the bank: 488M vs. SPRO (31.2M). SPRO has less debt than XENE: SPRO (3.62M) vs XENE (8.72M). SPRO has higher revenues than XENE: SPRO (34.1M) vs XENE (7.5M).
SPROXENESPRO / XENE
Capitalization106M2.93B4%
EBITDA-56.36M-315.5M18%
Gain YTD83.495-3.112-2,683%
P/E Ratio10.75N/A-
Revenue34.1M7.5M455%
Total Cash31.2M488M6%
Total Debt3.62M8.72M41%
FUNDAMENTALS RATINGS
SPRO vs XENE: Fundamental Ratings
SPRO
XENE
OUTLOOK RATING
1..100
1265
VALUATION
overvalued / fair valued / undervalued
1..100
48
Fair valued
74
Overvalued
PROFIT vs RISK RATING
1..100
10039
SMR RATING
1..100
9997
PRICE GROWTH RATING
1..100
4252
P/E GROWTH RATING
1..100
76
SEASONALITY SCORE
1..100
485

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

SPRO's Valuation (48) in the Pharmaceuticals Major industry is in the same range as XENE (74) in the Biotechnology industry. This means that SPRO’s stock grew similarly to XENE’s over the last 12 months.

XENE's Profit vs Risk Rating (39) in the Biotechnology industry is somewhat better than the same rating for SPRO (100) in the Pharmaceuticals Major industry. This means that XENE’s stock grew somewhat faster than SPRO’s over the last 12 months.

XENE's SMR Rating (97) in the Biotechnology industry is in the same range as SPRO (99) in the Pharmaceuticals Major industry. This means that XENE’s stock grew similarly to SPRO’s over the last 12 months.

SPRO's Price Growth Rating (42) in the Pharmaceuticals Major industry is in the same range as XENE (52) in the Biotechnology industry. This means that SPRO’s stock grew similarly to XENE’s over the last 12 months.

XENE's P/E Growth Rating (6) in the Biotechnology industry is in the same range as SPRO (7) in the Pharmaceuticals Major industry. This means that XENE’s stock grew similarly to SPRO’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
SPROXENE
RSI
ODDS (%)
Bullish Trend 6 days ago
73%
Bearish Trend 3 days ago
61%
Stochastic
ODDS (%)
Bearish Trend 3 days ago
88%
Bullish Trend 3 days ago
82%
Momentum
ODDS (%)
Bearish Trend 3 days ago
90%
Bullish Trend 3 days ago
76%
MACD
ODDS (%)
Bullish Trend 3 days ago
76%
Bearish Trend 3 days ago
73%
TrendWeek
ODDS (%)
Bearish Trend 3 days ago
89%
Bullish Trend 3 days ago
74%
TrendMonth
ODDS (%)
Bullish Trend 3 days ago
76%
Bearish Trend 3 days ago
73%
Advances
ODDS (%)
Bullish Trend 24 days ago
71%
Bullish Trend 11 days ago
73%
Declines
ODDS (%)
Bearish Trend 3 days ago
90%
Bearish Trend 4 days ago
71%
BollingerBands
ODDS (%)
N/A
Bullish Trend 3 days ago
76%
Aroon
ODDS (%)
Bearish Trend 3 days ago
89%
Bullish Trend 3 days ago
79%
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SPRO
Daily Signalchanged days ago
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XENE
Daily Signalchanged days ago
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SPRO and

Correlation & Price change

A.I.dvisor indicates that over the last year, SPRO has been loosely correlated with ASBP. These tickers have moved in lockstep 62% of the time. This A.I.-generated data suggests there is some statistical probability that if SPRO jumps, then ASBP could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SPRO
1D Price
Change %
SPRO100%
-2.58%
ASBP - SPRO
62%
Loosely correlated
-4.95%
CLGN - SPRO
42%
Loosely correlated
+10.95%
IMNN - SPRO
41%
Loosely correlated
-0.19%
XENE - SPRO
32%
Poorly correlated
+4.00%
SYRE - SPRO
31%
Poorly correlated
+4.04%
More

XENE and

Correlation & Price change

A.I.dvisor indicates that over the last year, XENE has been loosely correlated with NUVL. These tickers have moved in lockstep 60% of the time. This A.I.-generated data suggests there is some statistical probability that if XENE jumps, then NUVL could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To XENE
1D Price
Change %
XENE100%
+4.00%
NUVL - XENE
60%
Loosely correlated
+4.99%
IDYA - XENE
56%
Loosely correlated
+4.44%
CRNX - XENE
54%
Loosely correlated
+27.92%
IMVT - XENE
52%
Loosely correlated
+3.57%
ATXS - XENE
51%
Loosely correlated
+2.10%
More