SPRB
Price
$84.00
Change
+$0.26 (+0.31%)
Updated
Dec 24 closing price
Capitalization
89.91M
Intraday BUY SELL Signals
VYNE
Price
$0.58
Change
+$0.01 (+1.75%)
Updated
Dec 24 closing price
Capitalization
19.39M
Intraday BUY SELL Signals
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SPRB vs VYNE

Header iconSPRB vs VYNE Comparison
Open Charts SPRB vs VYNEBanner chart's image
Spruce Biosciences
Price$84.00
Change+$0.26 (+0.31%)
Volume$14.21K
Capitalization89.91M
VYNE Therapeutics
Price$0.58
Change+$0.01 (+1.75%)
Volume$957.87K
Capitalization19.39M
SPRB vs VYNE Comparison Chart in %
SPRB
Daily Signal:
Gain/Loss:
VYNE
Daily Signal:
Gain/Loss:
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VS
SPRB vs. VYNE commentary
Dec 25, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is SPRB is a Hold and VYNE is a StrongBuy.

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COMPARISON
Comparison
Dec 25, 2025
Stock price -- (SPRB: $84.00 vs. VYNE: $0.58)
Brand notoriety: SPRB and VYNE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: SPRB: 10% vs. VYNE: 13%
Market capitalization -- SPRB: $89.91M vs. VYNE: $19.39M
SPRB [@Biotechnology] is valued at $89.91M. VYNE’s [@Biotechnology] market capitalization is $19.39M. The market cap for tickers in the [@Biotechnology] industry ranges from $117.47B to $0. The average market capitalization across the [@Biotechnology] industry is $2.23B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

SPRB’s FA Score shows that 0 FA rating(s) are green whileVYNE’s FA Score has 2 green FA rating(s).

  • SPRB’s FA Score: 0 green, 5 red.
  • VYNE’s FA Score: 2 green, 3 red.
According to our system of comparison, VYNE is a better buy in the long-term than SPRB.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

SPRB’s TA Score shows that 4 TA indicator(s) are bullish while VYNE’s TA Score has 5 bullish TA indicator(s).

  • SPRB’s TA Score: 4 bullish, 5 bearish.
  • VYNE’s TA Score: 5 bullish, 4 bearish.
According to our system of comparison, VYNE is a better buy in the short-term than SPRB.

Price Growth

SPRB (@Biotechnology) experienced а +10.76% price change this week, while VYNE (@Biotechnology) price change was -2.92% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +2.88%. For the same industry, the average monthly price growth was +4.46%, and the average quarterly price growth was +55.39%.

Industries' Descriptions

@Biotechnology (+2.88% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
SPRB($89.9M) has a higher market cap than VYNE($19.4M). SPRB YTD gains are higher at: 166.667 vs. VYNE (-82.612). VYNE has higher annual earnings (EBITDA): -37.28M vs. SPRB (-47.71M). VYNE has more cash in the bank: 32.7M vs. SPRB (10.7M). VYNE has less debt than SPRB: VYNE (0) vs SPRB (1.35M). SPRB has higher revenues than VYNE: SPRB (697K) vs VYNE (524K).
SPRBVYNESPRB / VYNE
Capitalization89.9M19.4M463%
EBITDA-47.71M-37.28M128%
Gain YTD166.667-82.612-202%
P/E RatioN/A0.71-
Revenue697K524K133%
Total Cash10.7M32.7M33%
Total Debt1.35M0-
FUNDAMENTALS RATINGS
VYNE: Fundamental Ratings
VYNE
OUTLOOK RATING
1..100
35
VALUATION
overvalued / fair valued / undervalued
1..100
26
Undervalued
PROFIT vs RISK RATING
1..100
100
SMR RATING
1..100
98
PRICE GROWTH RATING
1..100
40
P/E GROWTH RATING
1..100
1
SEASONALITY SCORE
1..100
34

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

TECHNICAL ANALYSIS
Technical Analysis
SPRBVYNE
RSI
ODDS (%)
N/A
Bearish Trend 2 days ago
90%
Stochastic
ODDS (%)
Bullish Trend 2 days ago
77%
Bearish Trend 2 days ago
90%
Momentum
ODDS (%)
Bearish Trend 2 days ago
88%
Bullish Trend 2 days ago
82%
MACD
ODDS (%)
Bullish Trend 2 days ago
82%
Bullish Trend 2 days ago
78%
TrendWeek
ODDS (%)
Bullish Trend 2 days ago
81%
Bearish Trend 2 days ago
89%
TrendMonth
ODDS (%)
Bearish Trend 2 days ago
89%
Bullish Trend 2 days ago
77%
Advances
ODDS (%)
Bullish Trend 2 days ago
78%
Bullish Trend 9 days ago
81%
Declines
ODDS (%)
Bearish Trend 9 days ago
88%
Bearish Trend 3 days ago
88%
BollingerBands
ODDS (%)
Bullish Trend 2 days ago
76%
Bearish Trend 2 days ago
82%
Aroon
ODDS (%)
Bearish Trend 2 days ago
88%
Bullish Trend 2 days ago
79%
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SPRB
Daily Signal:
Gain/Loss:
VYNE
Daily Signal:
Gain/Loss:
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SPRB and

Correlation & Price change

A.I.dvisor indicates that over the last year, SPRB has been loosely correlated with NEVPF. These tickers have moved in lockstep 61% of the time. This A.I.-generated data suggests there is some statistical probability that if SPRB jumps, then NEVPF could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SPRB
1D Price
Change %
SPRB100%
+0.31%
NEVPF - SPRB
61%
Loosely correlated
N/A
IMRX - SPRB
52%
Loosely correlated
+6.57%
MLEC - SPRB
51%
Loosely correlated
-3.02%
IMCR - SPRB
37%
Loosely correlated
+1.05%
VYNE - SPRB
35%
Loosely correlated
+2.48%
More

VYNE and

Correlation & Price change

A.I.dvisor indicates that over the last year, VYNE has been loosely correlated with NEVPF. These tickers have moved in lockstep 52% of the time. This A.I.-generated data suggests there is some statistical probability that if VYNE jumps, then NEVPF could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To VYNE
1D Price
Change %
VYNE100%
+2.48%
NEVPF - VYNE
52%
Loosely correlated
N/A
CRDF - VYNE
38%
Loosely correlated
+9.28%
SYRE - VYNE
36%
Loosely correlated
-0.54%
ABVX - VYNE
34%
Loosely correlated
+5.03%
EYPT - VYNE
32%
Poorly correlated
-0.65%
More