PTCT
Price
$59.50
Change
-$1.06 (-1.75%)
Updated
Sep 24 closing price
Capitalization
4.73B
28 days until earnings call
SYRE
Price
$17.00
Change
+$0.98 (+6.12%)
Updated
Sep 24 closing price
Capitalization
1.03B
42 days until earnings call
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PTCT vs SYRE

Header iconPTCT vs SYRE Comparison
Open Charts PTCT vs SYREBanner chart's image
PTC Therapeutics
Price$59.50
Change-$1.06 (-1.75%)
Volume$1.17M
Capitalization4.73B
Spyre Therapeutics
Price$17.00
Change+$0.98 (+6.12%)
Volume$753.11K
Capitalization1.03B
PTCT vs SYRE Comparison Chart in %
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PTCT
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE
Daily Signalchanged days ago
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PTCT vs. SYRE commentary
Sep 25, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is PTCT is a Buy and SYRE is a StrongBuy.

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COMPARISON
Comparison
Sep 25, 2025
Stock price -- (PTCT: $59.50 vs. SYRE: $17.00)
Brand notoriety: PTCT and SYRE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: PTCT: 87% vs. SYRE: 139%
Market capitalization -- PTCT: $4.73B vs. SYRE: $1.03B
PTCT [@Biotechnology] is valued at $4.73B. SYRE’s [@Biotechnology] market capitalization is $1.03B. The market cap for tickers in the [@Biotechnology] industry ranges from $96.56B to $0. The average market capitalization across the [@Biotechnology] industry is $1.91B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

PTCT’s FA Score shows that 1 FA rating(s) are green whileSYRE’s FA Score has 0 green FA rating(s).

  • PTCT’s FA Score: 1 green, 4 red.
  • SYRE’s FA Score: 0 green, 5 red.
According to our system of comparison, PTCT is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

PTCT’s TA Score shows that 5 TA indicator(s) are bullish while SYRE’s TA Score has 7 bullish TA indicator(s).

  • PTCT’s TA Score: 5 bullish, 5 bearish.
  • SYRE’s TA Score: 7 bullish, 3 bearish.
According to our system of comparison, SYRE is a better buy in the short-term than PTCT.

Price Growth

PTCT (@Biotechnology) experienced а -1.90% price change this week, while SYRE (@Biotechnology) price change was +12.96% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +4.93%. For the same industry, the average monthly price growth was +10.45%, and the average quarterly price growth was +53.75%.

Reported Earning Dates

PTCT is expected to report earnings on Oct 23, 2025.

SYRE is expected to report earnings on Nov 06, 2025.

Industries' Descriptions

@Biotechnology (+4.93% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
PTCT($4.73B) has a higher market cap than SYRE($1.03B). PTCT has higher P/E ratio than SYRE: PTCT (8.44) vs SYRE (1.68). PTCT YTD gains are higher at: 31.812 vs. SYRE (-26.976). PTCT has higher annual earnings (EBITDA): 841M vs. SYRE (-222.15M). PTCT has more cash in the bank: 1.99B vs. SYRE (527M). SYRE has less debt than PTCT: SYRE (0) vs PTCT (388M). PTCT has higher revenues than SYRE: PTCT (1.77B) vs SYRE (0).
PTCTSYREPTCT / SYRE
Capitalization4.73B1.03B460%
EBITDA841M-222.15M-379%
Gain YTD31.812-26.976-118%
P/E Ratio8.441.68501%
Revenue1.77B0-
Total Cash1.99B527M377%
Total Debt388M0-
FUNDAMENTALS RATINGS
PTCT vs SYRE: Fundamental Ratings
PTCT
SYRE
OUTLOOK RATING
1..100
1913
VALUATION
overvalued / fair valued / undervalued
1..100
100
Overvalued
72
Overvalued
PROFIT vs RISK RATING
1..100
81100
SMR RATING
1..100
10098
PRICE GROWTH RATING
1..100
4164
P/E GROWTH RATING
1..100
1480
SEASONALITY SCORE
1..100
n/an/a

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

SYRE's Valuation (72) in the Pharmaceuticals Major industry is in the same range as PTCT (100) in the Biotechnology industry. This means that SYRE’s stock grew similarly to PTCT’s over the last 12 months.

PTCT's Profit vs Risk Rating (81) in the Biotechnology industry is in the same range as SYRE (100) in the Pharmaceuticals Major industry. This means that PTCT’s stock grew similarly to SYRE’s over the last 12 months.

SYRE's SMR Rating (98) in the Pharmaceuticals Major industry is in the same range as PTCT (100) in the Biotechnology industry. This means that SYRE’s stock grew similarly to PTCT’s over the last 12 months.

PTCT's Price Growth Rating (41) in the Biotechnology industry is in the same range as SYRE (64) in the Pharmaceuticals Major industry. This means that PTCT’s stock grew similarly to SYRE’s over the last 12 months.

PTCT's P/E Growth Rating (14) in the Biotechnology industry is significantly better than the same rating for SYRE (80) in the Pharmaceuticals Major industry. This means that PTCT’s stock grew significantly faster than SYRE’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
PTCTSYRE
RSI
ODDS (%)
Bearish Trend 1 day ago
89%
Bullish Trend 1 day ago
90%
Stochastic
ODDS (%)
Bearish Trend 1 day ago
80%
Bullish Trend 1 day ago
89%
Momentum
ODDS (%)
Bullish Trend 1 day ago
76%
Bullish Trend 1 day ago
84%
MACD
ODDS (%)
Bearish Trend 1 day ago
83%
Bullish Trend 1 day ago
87%
TrendWeek
ODDS (%)
Bearish Trend 1 day ago
78%
Bullish Trend 1 day ago
83%
TrendMonth
ODDS (%)
Bullish Trend 1 day ago
75%
Bearish Trend 1 day ago
89%
Advances
ODDS (%)
Bullish Trend 8 days ago
74%
Bullish Trend 1 day ago
84%
Declines
ODDS (%)
Bearish Trend 1 day ago
81%
Bearish Trend 10 days ago
90%
BollingerBands
ODDS (%)
Bearish Trend 1 day ago
90%
Bullish Trend 1 day ago
85%
Aroon
ODDS (%)
Bullish Trend 1 day ago
78%
Bearish Trend 1 day ago
89%
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PTCT
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE
Daily Signalchanged days ago
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PTCT and

Correlation & Price change

A.I.dvisor indicates that over the last year, PTCT has been loosely correlated with ACLX. These tickers have moved in lockstep 49% of the time. This A.I.-generated data suggests there is some statistical probability that if PTCT jumps, then ACLX could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To PTCT
1D Price
Change %
PTCT100%
-1.75%
ACLX - PTCT
49%
Loosely correlated
-0.51%
XNCR - PTCT
43%
Loosely correlated
+1.45%
SYRE - PTCT
43%
Loosely correlated
+6.12%
IMVT - PTCT
43%
Loosely correlated
+3.76%
BHVN - PTCT
42%
Loosely correlated
-2.97%
More

SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with CGON. These tickers have moved in lockstep 59% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then CGON could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
+6.12%
CGON - SYRE
59%
Loosely correlated
-0.05%
IDYA - SYRE
59%
Loosely correlated
-1.00%
XNCR - SYRE
57%
Loosely correlated
+1.45%
CRNX - SYRE
56%
Loosely correlated
-1.90%
BEAM - SYRE
55%
Loosely correlated
-0.59%
More