ORKA
Price
$32.12
Change
+$0.41 (+1.29%)
Updated
Dec 24 closing price
Capitalization
1.55B
Intraday BUY SELL Signals
UPB
Price
$30.27
Change
+$1.06 (+3.63%)
Updated
Dec 24 closing price
Capitalization
1.64B
82 days until earnings call
Intraday BUY SELL Signals
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ORKA vs UPB

Header iconORKA vs UPB Comparison
Open Charts ORKA vs UPBBanner chart's image
Oruka Therapeutics
Price$32.12
Change+$0.41 (+1.29%)
Volume$261.98K
Capitalization1.55B
Upstream Bio
Price$30.27
Change+$1.06 (+3.63%)
Volume$266.48K
Capitalization1.64B
ORKA vs UPB Comparison Chart in %
ORKA
Daily Signal:
Gain/Loss:
UPB
Daily Signal:
Gain/Loss:
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VS
ORKA vs. UPB commentary
Dec 26, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is ORKA is a StrongBuy and UPB is a StrongBuy.

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COMPARISON
Comparison
Dec 26, 2025
Stock price -- (ORKA: $32.12 vs. UPB: $30.27)
Brand notoriety: ORKA and UPB are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: ORKA: 51% vs. UPB: 53%
Market capitalization -- ORKA: $1.55B vs. UPB: $1.64B
ORKA [@Biotechnology] is valued at $1.55B. UPB’s [@Biotechnology] market capitalization is $1.64B. The market cap for tickers in the [@Biotechnology] industry ranges from $117.47B to $0. The average market capitalization across the [@Biotechnology] industry is $2.23B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

ORKA’s FA Score shows that 1 FA rating(s) are green whileUPB’s FA Score has 0 green FA rating(s).

  • ORKA’s FA Score: 1 green, 4 red.
  • UPB’s FA Score: 0 green, 5 red.
According to our system of comparison, ORKA is a better buy in the long-term than UPB.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

ORKA’s TA Score shows that 5 TA indicator(s) are bullish while UPB’s TA Score has 4 bullish TA indicator(s).

  • ORKA’s TA Score: 5 bullish, 3 bearish.
  • UPB’s TA Score: 4 bullish, 3 bearish.
According to our system of comparison, ORKA is a better buy in the short-term than UPB.

Price Growth

ORKA (@Biotechnology) experienced а +13.18% price change this week, while UPB (@Biotechnology) price change was +6.85% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +2.88%. For the same industry, the average monthly price growth was +4.46%, and the average quarterly price growth was +55.39%.

Reported Earning Dates

UPB is expected to report earnings on Mar 18, 2026.

Industries' Descriptions

@Biotechnology (+2.88% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
UPB($1.64B) has a higher market cap than ORKA($1.56B). UPB YTD gains are higher at: 84.124 vs. ORKA (65.652). UPB has more cash in the bank: 372M vs. ORKA (349M). UPB has less debt than ORKA: UPB (1.42M) vs ORKA (1.91M).
ORKAUPBORKA / UPB
Capitalization1.56B1.64B95%
EBITDAN/A-140.33M-
Gain YTD65.65284.12478%
P/E RatioN/AN/A-
RevenueN/A2.8M-
Total Cash349M372M94%
Total Debt1.91M1.42M135%
FUNDAMENTALS RATINGS
ORKA: Fundamental Ratings
ORKA
OUTLOOK RATING
1..100
89
VALUATION
overvalued / fair valued / undervalued
1..100
5
Undervalued
PROFIT vs RISK RATING
1..100
100
SMR RATING
1..100
100
PRICE GROWTH RATING
1..100
35
P/E GROWTH RATING
1..100
100
SEASONALITY SCORE
1..100
85

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

TECHNICAL ANALYSIS
Technical Analysis
ORKAUPB
RSI
ODDS (%)
N/A
Bearish Trend 3 days ago
55%
Stochastic
ODDS (%)
Bearish Trend 3 days ago
70%
Bearish Trend 3 days ago
90%
Momentum
ODDS (%)
Bullish Trend 3 days ago
67%
Bullish Trend 3 days ago
80%
MACD
ODDS (%)
Bullish Trend 3 days ago
71%
Bullish Trend 3 days ago
75%
TrendWeek
ODDS (%)
Bullish Trend 3 days ago
67%
Bullish Trend 3 days ago
90%
TrendMonth
ODDS (%)
Bullish Trend 3 days ago
69%
Bullish Trend 3 days ago
90%
Advances
ODDS (%)
Bullish Trend 5 days ago
75%
Bullish Trend 19 days ago
89%
Declines
ODDS (%)
Bearish Trend 9 days ago
77%
N/A
BollingerBands
ODDS (%)
Bearish Trend 3 days ago
79%
Bearish Trend 3 days ago
85%
Aroon
ODDS (%)
Bullish Trend 3 days ago
79%
Bullish Trend 3 days ago
90%
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ORKA
Daily Signal:
Gain/Loss:
UPB
Daily Signal:
Gain/Loss:
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ORKA and

Correlation & Price change

A.I.dvisor indicates that over the last year, ORKA has been loosely correlated with SYRE. These tickers have moved in lockstep 56% of the time. This A.I.-generated data suggests there is some statistical probability that if ORKA jumps, then SYRE could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To ORKA
1D Price
Change %
ORKA100%
+1.29%
SYRE - ORKA
56%
Loosely correlated
-0.54%
ELVN - ORKA
47%
Loosely correlated
+1.21%
VRDN - ORKA
46%
Loosely correlated
+0.53%
ATXS - ORKA
46%
Loosely correlated
+0.62%
APGE - ORKA
46%
Loosely correlated
+1.02%
More

UPB and

Correlation & Price change

A.I.dvisor indicates that over the last year, UPB has been loosely correlated with IPSC. These tickers have moved in lockstep 42% of the time. This A.I.-generated data suggests there is some statistical probability that if UPB jumps, then IPSC could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To UPB
1D Price
Change %
UPB100%
+3.63%
IPSC - UPB
42%
Loosely correlated
+6.19%
IDYA - UPB
41%
Loosely correlated
+0.76%
VYGR - UPB
41%
Loosely correlated
+2.01%
SYRE - UPB
41%
Loosely correlated
-0.54%
ORKA - UPB
40%
Loosely correlated
+1.29%
More