MREO
Price
$2.02
Change
+$0.06 (+3.06%)
Updated
Dec 4, 04:59 PM (EDT)
Capitalization
324.63M
117 days until earnings call
Intraday BUY SELL Signals
SYRE
Price
$33.53
Change
+$1.33 (+4.13%)
Updated
Dec 4, 04:59 PM (EDT)
Capitalization
2.5B
84 days until earnings call
Intraday BUY SELL Signals
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MREO vs SYRE

Header iconMREO vs SYRE Comparison
Open Charts MREO vs SYREBanner chart's image
Mereo BioPharma Group
Price$2.02
Change+$0.06 (+3.06%)
Volume$111.22K
Capitalization324.63M
Spyre Therapeutics
Price$33.53
Change+$1.33 (+4.13%)
Volume$14.2K
Capitalization2.5B
MREO vs SYRE Comparison Chart in %
MREO
Daily Signal:
Gain/Loss:
SYRE
Daily Signal:
Gain/Loss:
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VS
MREO vs. SYRE commentary
Dec 05, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is MREO is a Buy and SYRE is a Buy.

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COMPARISON
Comparison
Dec 05, 2025
Stock price -- (MREO: $1.96 vs. SYRE: $32.20)
Brand notoriety: MREO and SYRE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: MREO: 683% vs. SYRE: 137%
Market capitalization -- MREO: $324.63M vs. SYRE: $2.6B
MREO [@Biotechnology] is valued at $324.63M. SYRE’s [@Biotechnology] market capitalization is $2.6B. The market cap for tickers in the [@Biotechnology] industry ranges from $117.5B to $0. The average market capitalization across the [@Biotechnology] industry is $2.2B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

MREO’s FA Score shows that 1 FA rating(s) are green whileSYRE’s FA Score has 0 green FA rating(s).

  • MREO’s FA Score: 1 green, 4 red.
  • SYRE’s FA Score: 0 green, 5 red.
According to our system of comparison, MREO is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

MREO’s TA Score shows that 5 TA indicator(s) are bullish while SYRE’s TA Score has 4 bullish TA indicator(s).

  • MREO’s TA Score: 5 bullish, 4 bearish.
  • SYRE’s TA Score: 4 bullish, 4 bearish.
According to our system of comparison, MREO is a better buy in the short-term than SYRE.

Price Growth

MREO (@Biotechnology) experienced а +6.52% price change this week, while SYRE (@Biotechnology) price change was +8.24% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +1.21%. For the same industry, the average monthly price growth was +5.86%, and the average quarterly price growth was +56.03%.

Reported Earning Dates

MREO is expected to report earnings on Apr 01, 2026.

SYRE is expected to report earnings on Feb 26, 2026.

Industries' Descriptions

@Biotechnology (+1.21% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
SYRE($2.5B) has a higher market cap than MREO($325M). SYRE YTD gains are higher at: 38.316 vs. MREO (-44.000). MREO has higher annual earnings (EBITDA): -47.49M vs. SYRE (-222.15M). SYRE has more cash in the bank: 527M vs. MREO (56.1M). SYRE has less debt than MREO: SYRE (0) vs MREO (601K). MREO has higher revenues than SYRE: MREO (500K) vs SYRE (0).
MREOSYREMREO / SYRE
Capitalization325M2.5B13%
EBITDA-47.49M-222.15M21%
Gain YTD-44.00038.316-115%
P/E RatioN/A1.72-
Revenue500K0-
Total Cash56.1M527M11%
Total Debt601K0-
FUNDAMENTALS RATINGS
MREO vs SYRE: Fundamental Ratings
MREO
SYRE
OUTLOOK RATING
1..100
2315
VALUATION
overvalued / fair valued / undervalued
1..100
75
Overvalued
69
Overvalued
PROFIT vs RISK RATING
1..100
100100
SMR RATING
1..100
9897
PRICE GROWTH RATING
1..100
6437
P/E GROWTH RATING
1..100
175
SEASONALITY SCORE
1..100
n/an/a

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

SYRE's Valuation (69) in the Pharmaceuticals Major industry is in the same range as MREO (75) in the null industry. This means that SYRE’s stock grew similarly to MREO’s over the last 12 months.

SYRE's Profit vs Risk Rating (100) in the Pharmaceuticals Major industry is in the same range as MREO (100) in the null industry. This means that SYRE’s stock grew similarly to MREO’s over the last 12 months.

SYRE's SMR Rating (97) in the Pharmaceuticals Major industry is in the same range as MREO (98) in the null industry. This means that SYRE’s stock grew similarly to MREO’s over the last 12 months.

SYRE's Price Growth Rating (37) in the Pharmaceuticals Major industry is in the same range as MREO (64) in the null industry. This means that SYRE’s stock grew similarly to MREO’s over the last 12 months.

MREO's P/E Growth Rating (1) in the null industry is significantly better than the same rating for SYRE (75) in the Pharmaceuticals Major industry. This means that MREO’s stock grew significantly faster than SYRE’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
MREOSYRE
RSI
ODDS (%)
N/A
Bearish Trend 2 days ago
90%
Stochastic
ODDS (%)
Bullish Trend 2 days ago
75%
Bearish Trend 2 days ago
90%
Momentum
ODDS (%)
Bullish Trend 2 days ago
88%
Bullish Trend 2 days ago
82%
MACD
ODDS (%)
Bullish Trend 2 days ago
73%
Bullish Trend 2 days ago
84%
TrendWeek
ODDS (%)
Bullish Trend 2 days ago
81%
Bullish Trend 2 days ago
84%
TrendMonth
ODDS (%)
Bullish Trend 2 days ago
83%
Bullish Trend 2 days ago
83%
Advances
ODDS (%)
Bullish Trend 7 days ago
81%
Bullish Trend 7 days ago
85%
Declines
ODDS (%)
Bearish Trend 15 days ago
85%
Bearish Trend 29 days ago
90%
BollingerBands
ODDS (%)
Bearish Trend 2 days ago
86%
Bearish Trend 2 days ago
90%
Aroon
ODDS (%)
Bearish Trend 2 days ago
89%
Bullish Trend 2 days ago
81%
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MREO
Daily Signal:
Gain/Loss:
SYRE
Daily Signal:
Gain/Loss:
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MREO and

Correlation & Price change

A.I.dvisor indicates that over the last year, MREO has been closely correlated with RARE. These tickers have moved in lockstep 69% of the time. This A.I.-generated data suggests there is a high statistical probability that if MREO jumps, then RARE could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To MREO
1D Price
Change %
MREO100%
+12.00%
RARE - MREO
69%
Closely correlated
+8.90%
TRDA - MREO
42%
Loosely correlated
+2.23%
SYRE - MREO
39%
Loosely correlated
+13.38%
XNCR - MREO
38%
Loosely correlated
+8.26%
NRIX - MREO
38%
Loosely correlated
+2.94%
More

SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with APGE. These tickers have moved in lockstep 58% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then APGE could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
+13.38%
APGE - SYRE
58%
Loosely correlated
+7.84%
CGON - SYRE
58%
Loosely correlated
+3.00%
RGNX - SYRE
57%
Loosely correlated
+5.49%
ORKA - SYRE
57%
Loosely correlated
+6.36%
IDYA - SYRE
56%
Loosely correlated
+1.93%
More