KRYS
Price
$204.71
Change
+$3.50 (+1.74%)
Updated
Nov 14, 12:36 PM (EDT)
Capitalization
5.82B
108 days until earnings call
Intraday BUY SELL Signals
VRTX
Price
$434.52
Change
+$0.33 (+0.08%)
Updated
Nov 13 closing price
Capitalization
110.25B
82 days until earnings call
Intraday BUY SELL Signals
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KRYS vs VRTX

Header iconKRYS vs VRTX Comparison
Open Charts KRYS vs VRTXBanner chart's image
Krystal Biotech
Price$204.71
Change+$3.50 (+1.74%)
Volume$1.75K
Capitalization5.82B
Vertex Pharmaceuticals
Price$434.52
Change+$0.33 (+0.08%)
Volume$1.56M
Capitalization110.25B
KRYS vs VRTX Comparison Chart in %
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VS
KRYS vs. VRTX commentary
Nov 14, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is KRYS is a Hold and VRTX is a Buy.

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COMPARISON
Comparison
Nov 14, 2025
Stock price -- (KRYS: $201.21 vs. VRTX: $434.52)
Brand notoriety: KRYS and VRTX are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: KRYS: 58% vs. VRTX: 103%
Market capitalization -- KRYS: $5.82B vs. VRTX: $110.25B
KRYS [@Biotechnology] is valued at $5.82B. VRTX’s [@Biotechnology] market capitalization is $110.25B. The market cap for tickers in the [@Biotechnology] industry ranges from $110.25B to $0. The average market capitalization across the [@Biotechnology] industry is $2.11B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

KRYS’s FA Score shows that 1 FA rating(s) are green whileVRTX’s FA Score has 2 green FA rating(s).

  • KRYS’s FA Score: 1 green, 4 red.
  • VRTX’s FA Score: 2 green, 3 red.
According to our system of comparison, VRTX is a better buy in the long-term than KRYS.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

KRYS’s TA Score shows that 4 TA indicator(s) are bullish while VRTX’s TA Score has 4 bullish TA indicator(s).

  • KRYS’s TA Score: 4 bullish, 5 bearish.
  • VRTX’s TA Score: 4 bullish, 4 bearish.
According to our system of comparison, VRTX is a better buy in the short-term than KRYS.

Price Growth

KRYS (@Biotechnology) experienced а +0.62% price change this week, while VRTX (@Biotechnology) price change was +4.39% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +3.64%. For the same industry, the average monthly price growth was -3.56%, and the average quarterly price growth was +66.73%.

Reported Earning Dates

KRYS is expected to report earnings on Mar 02, 2026.

VRTX is expected to report earnings on Feb 04, 2026.

Industries' Descriptions

@Biotechnology (+3.64% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
VRTX($110B) has a higher market cap than KRYS($5.82B). VRTX (30.58) and KRYS (30.17) have similar P/E ratio . KRYS YTD gains are higher at: 28.437 vs. VRTX (7.820). VRTX has higher annual earnings (EBITDA): 4.59B vs. KRYS (158M). VRTX has more cash in the bank: 6.38B vs. KRYS (682M). KRYS has less debt than VRTX: KRYS (9.68M) vs VRTX (1.53B). VRTX has higher revenues than KRYS: VRTX (11.4B) vs KRYS (359M).
KRYSVRTXKRYS / VRTX
Capitalization5.82B110B5%
EBITDA158M4.59B3%
Gain YTD28.4377.820364%
P/E Ratio30.1730.5899%
Revenue359M11.4B3%
Total Cash682M6.38B11%
Total Debt9.68M1.53B1%
FUNDAMENTALS RATINGS
KRYS vs VRTX: Fundamental Ratings
KRYS
VRTX
OUTLOOK RATING
1..100
2116
VALUATION
overvalued / fair valued / undervalued
1..100
75
Overvalued
79
Overvalued
PROFIT vs RISK RATING
1..100
2833
SMR RATING
1..100
5341
PRICE GROWTH RATING
1..100
4053
P/E GROWTH RATING
1..100
9828
SEASONALITY SCORE
1..100
85n/a

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

KRYS's Valuation (75) in the Pharmaceuticals Major industry is in the same range as VRTX (79) in the Biotechnology industry. This means that KRYS’s stock grew similarly to VRTX’s over the last 12 months.

KRYS's Profit vs Risk Rating (28) in the Pharmaceuticals Major industry is in the same range as VRTX (33) in the Biotechnology industry. This means that KRYS’s stock grew similarly to VRTX’s over the last 12 months.

VRTX's SMR Rating (41) in the Biotechnology industry is in the same range as KRYS (53) in the Pharmaceuticals Major industry. This means that VRTX’s stock grew similarly to KRYS’s over the last 12 months.

KRYS's Price Growth Rating (40) in the Pharmaceuticals Major industry is in the same range as VRTX (53) in the Biotechnology industry. This means that KRYS’s stock grew similarly to VRTX’s over the last 12 months.

VRTX's P/E Growth Rating (28) in the Biotechnology industry is significantly better than the same rating for KRYS (98) in the Pharmaceuticals Major industry. This means that VRTX’s stock grew significantly faster than KRYS’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
KRYSVRTX
RSI
ODDS (%)
Bearish Trend 2 days ago
71%
Bearish Trend 3 days ago
46%
Stochastic
ODDS (%)
Bearish Trend 2 days ago
74%
Bearish Trend 3 days ago
58%
Momentum
ODDS (%)
Bullish Trend 2 days ago
81%
Bullish Trend 3 days ago
58%
MACD
ODDS (%)
Bearish Trend 2 days ago
78%
Bullish Trend 3 days ago
48%
TrendWeek
ODDS (%)
Bullish Trend 2 days ago
79%
Bullish Trend 3 days ago
57%
TrendMonth
ODDS (%)
Bullish Trend 2 days ago
80%
Bullish Trend 3 days ago
62%
Advances
ODDS (%)
Bullish Trend 3 days ago
80%
Bullish Trend 3 days ago
59%
Declines
ODDS (%)
Bearish Trend 24 days ago
74%
Bearish Trend 8 days ago
40%
BollingerBands
ODDS (%)
Bearish Trend 2 days ago
77%
Bearish Trend 3 days ago
56%
Aroon
ODDS (%)
Bullish Trend 2 days ago
74%
Bullish Trend 3 days ago
61%
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KRYS
Daily Signal:
Gain/Loss:
VRTX
Daily Signal:
Gain/Loss:
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KRYS and

Correlation & Price change

A.I.dvisor indicates that over the last year, KRYS has been loosely correlated with ACLX. These tickers have moved in lockstep 50% of the time. This A.I.-generated data suggests there is some statistical probability that if KRYS jumps, then ACLX could also see price increases.

1D
1W
1M
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1Y
5Y
Ticker /
NAME
Correlation
To KRYS
1D Price
Change %
KRYS100%
-0.90%
ACLX - KRYS
50%
Loosely correlated
-3.02%
VRDN - KRYS
49%
Loosely correlated
-1.55%
IDYA - KRYS
49%
Loosely correlated
-0.41%
CGON - KRYS
48%
Loosely correlated
-4.19%
NUVL - KRYS
48%
Loosely correlated
-2.42%
More

VRTX and

Correlation & Price change

A.I.dvisor indicates that over the last year, VRTX has been loosely correlated with NEVPF. These tickers have moved in lockstep 47% of the time. This A.I.-generated data suggests there is some statistical probability that if VRTX jumps, then NEVPF could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To VRTX
1D Price
Change %
VRTX100%
+1.16%
NEVPF - VRTX
47%
Loosely correlated
N/A
SNDX - VRTX
41%
Loosely correlated
-5.30%
IDYA - VRTX
35%
Loosely correlated
-0.19%
KRYS - VRTX
33%
Poorly correlated
+0.01%
RGNX - VRTX
32%
Poorly correlated
+0.43%
More