DSGN
Price
$9.63
Change
-$0.11 (-1.13%)
Updated
Dec 26 closing price
Capitalization
548.56M
80 days until earnings call
Intraday BUY SELL Signals
UPB
Price
$29.48
Change
-$0.79 (-2.61%)
Updated
Dec 26 closing price
Capitalization
1.59B
80 days until earnings call
Intraday BUY SELL Signals
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DSGN vs UPB

Header iconDSGN vs UPB Comparison
Open Charts DSGN vs UPBBanner chart's image
Design Therapeutics
Price$9.63
Change-$0.11 (-1.13%)
Volume$111.45K
Capitalization548.56M
Upstream Bio
Price$29.48
Change-$0.79 (-2.61%)
Volume$228.01K
Capitalization1.59B
DSGN vs UPB Comparison Chart in %
DSGN
Daily Signal:
Gain/Loss:
UPB
Daily Signal:
Gain/Loss:
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VS
DSGN vs. UPB commentary
Dec 28, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is DSGN is a Buy and UPB is a StrongBuy.

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COMPARISON
Comparison
Dec 28, 2025
Stock price -- (DSGN: $9.63 vs. UPB: $29.48)
Brand notoriety: DSGN and UPB are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: DSGN: 26% vs. UPB: 47%
Market capitalization -- DSGN: $548.56M vs. UPB: $1.59B
DSGN [@Biotechnology] is valued at $548.56M. UPB’s [@Biotechnology] market capitalization is $1.59B. The market cap for tickers in the [@Biotechnology] industry ranges from $117.45B to $0. The average market capitalization across the [@Biotechnology] industry is $2.21B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

DSGN’s FA Score shows that 0 FA rating(s) are green whileUPB’s FA Score has 0 green FA rating(s).

  • DSGN’s FA Score: 0 green, 5 red.
  • UPB’s FA Score: 0 green, 5 red.
According to our system of comparison, UPB is a better buy in the long-term than DSGN.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

DSGN’s TA Score shows that 3 TA indicator(s) are bullish while UPB’s TA Score has 3 bullish TA indicator(s).

  • DSGN’s TA Score: 3 bullish, 4 bearish.
  • UPB’s TA Score: 3 bullish, 4 bearish.
According to our system of comparison, both DSGN and UPB are a bad buy in the short-term.

Price Growth

DSGN (@Biotechnology) experienced а -0.52% price change this week, while UPB (@Biotechnology) price change was +0.44% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +0.36%. For the same industry, the average monthly price growth was +0.27%, and the average quarterly price growth was +54.56%.

Reported Earning Dates

DSGN is expected to report earnings on Mar 17, 2026.

UPB is expected to report earnings on Mar 18, 2026.

Industries' Descriptions

@Biotechnology (+0.36% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
UPB($1.59B) has a higher market cap than DSGN($549M). UPB YTD gains are higher at: 79.319 vs. DSGN (56.078). DSGN has higher annual earnings (EBITDA): -77.38M vs. UPB (-140.33M). UPB has more cash in the bank: 372M vs. DSGN (206M). UPB has less debt than DSGN: UPB (1.42M) vs DSGN (1.74M). UPB has higher revenues than DSGN: UPB (2.8M) vs DSGN (0).
DSGNUPBDSGN / UPB
Capitalization549M1.59B34%
EBITDA-77.38M-140.33M55%
Gain YTD56.07879.31971%
P/E RatioN/AN/A-
Revenue02.8M-
Total Cash206M372M55%
Total Debt1.74M1.42M123%
TECHNICAL ANALYSIS
Technical Analysis
DSGNUPB
RSI
ODDS (%)
Bearish Trend 2 days ago
85%
Bearish Trend 2 days ago
55%
Stochastic
ODDS (%)
Bearish Trend 2 days ago
84%
Bearish Trend 2 days ago
73%
Momentum
ODDS (%)
Bullish Trend 2 days ago
90%
Bullish Trend 2 days ago
73%
MACD
ODDS (%)
Bearish Trend 2 days ago
86%
Bearish Trend 2 days ago
90%
TrendWeek
ODDS (%)
Bullish Trend 2 days ago
86%
Bearish Trend 2 days ago
81%
TrendMonth
ODDS (%)
Bullish Trend 2 days ago
87%
Bullish Trend 2 days ago
90%
Advances
ODDS (%)
Bullish Trend 6 days ago
89%
Bullish Trend 20 days ago
89%
Declines
ODDS (%)
N/A
N/A
BollingerBands
ODDS (%)
Bearish Trend 2 days ago
76%
Bearish Trend 2 days ago
69%
Aroon
ODDS (%)
Bullish Trend 2 days ago
82%
Bullish Trend 2 days ago
90%
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DSGN
Daily Signal:
Gain/Loss:
UPB
Daily Signal:
Gain/Loss:
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DSGN and

Correlation & Price change

A.I.dvisor indicates that over the last year, DSGN has been loosely correlated with IDYA. These tickers have moved in lockstep 51% of the time. This A.I.-generated data suggests there is some statistical probability that if DSGN jumps, then IDYA could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To DSGN
1D Price
Change %
DSGN100%
-1.13%
IDYA - DSGN
51%
Loosely correlated
-1.35%
SLDB - DSGN
49%
Loosely correlated
-1.02%
DYN - DSGN
49%
Loosely correlated
-1.52%
SYRE - DSGN
48%
Loosely correlated
-0.33%
AURA - DSGN
48%
Loosely correlated
-0.17%
More

UPB and

Correlation & Price change

A.I.dvisor indicates that over the last year, UPB has been loosely correlated with IDYA. These tickers have moved in lockstep 42% of the time. This A.I.-generated data suggests there is some statistical probability that if UPB jumps, then IDYA could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To UPB
1D Price
Change %
UPB100%
-2.61%
IDYA - UPB
42%
Loosely correlated
-1.35%
VYGR - UPB
41%
Loosely correlated
+0.25%
ORKA - UPB
40%
Loosely correlated
-1.31%
DSGN - UPB
39%
Loosely correlated
-1.13%
SYRE - UPB
39%
Loosely correlated
-0.33%
More