AXSM
Price
$147.81
Change
+$5.72 (+4.03%)
Updated
Dec 3 closing price
Capitalization
7.45B
88 days until earnings call
Intraday BUY SELL Signals
SYRE
Price
$32.20
Change
+$3.80 (+13.38%)
Updated
Dec 3, 04:59 PM (EDT)
Capitalization
2.22B
84 days until earnings call
Intraday BUY SELL Signals
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AXSM vs SYRE

Header iconAXSM vs SYRE Comparison
Open Charts AXSM vs SYREBanner chart's image
Axsome Therapeutics
Price$147.81
Change+$5.72 (+4.03%)
Volume$616.86K
Capitalization7.45B
Spyre Therapeutics
Price$32.20
Change+$3.80 (+13.38%)
Volume$57.92K
Capitalization2.22B
AXSM vs SYRE Comparison Chart in %
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AXSM vs. SYRE commentary
Dec 04, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is AXSM is a Hold and SYRE is a Hold.

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COMPARISON
Comparison
Dec 04, 2025
Stock price -- (AXSM: $141.96 vs. SYRE: $28.40)
Brand notoriety: AXSM and SYRE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: AXSM: 40% vs. SYRE: 23%
Market capitalization -- AXSM: $7.51B vs. SYRE: $2.22B
AXSM [@Biotechnology] is valued at $7.51B. SYRE’s [@Biotechnology] market capitalization is $2.22B. The market cap for tickers in the [@Biotechnology] industry ranges from $107.98B to $0. The average market capitalization across the [@Biotechnology] industry is $2.19B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

AXSM’s FA Score shows that 0 FA rating(s) are green whileSYRE’s FA Score has 0 green FA rating(s).

  • AXSM’s FA Score: 0 green, 5 red.
  • SYRE’s FA Score: 0 green, 5 red.
According to our system of comparison, AXSM is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

AXSM’s TA Score shows that 3 TA indicator(s) are bullish while SYRE’s TA Score has 4 bullish TA indicator(s).

  • AXSM’s TA Score: 3 bullish, 3 bearish.
  • SYRE’s TA Score: 4 bullish, 4 bearish.
According to our system of comparison, both AXSM and SYRE are a good buy in the short-term.

Price Growth

AXSM (@Biotechnology) experienced а -5.59% price change this week, while SYRE (@Biotechnology) price change was -2.74% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +0.32%. For the same industry, the average monthly price growth was +1.23%, and the average quarterly price growth was +54.93%.

Reported Earning Dates

AXSM is expected to report earnings on Mar 02, 2026.

SYRE is expected to report earnings on Feb 26, 2026.

Industries' Descriptions

@Biotechnology (+0.32% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
AXSM($7.45B) has a higher market cap than SYRE($2.22B). AXSM YTD gains are higher at: 67.782 vs. SYRE (21.993). SYRE (-222.15M) and AXSM (-230.81M) have comparable annual earnings (EBITDA) . SYRE has more cash in the bank: 527M vs. AXSM (303M). SYRE has less debt than AXSM: SYRE (0) vs AXSM (217M). AXSM has higher revenues than SYRE: AXSM (495M) vs SYRE (0).
AXSMSYREAXSM / SYRE
Capitalization7.45B2.22B335%
EBITDA-230.81M-222.15M104%
Gain YTD67.78221.993308%
P/E RatioN/A1.72-
Revenue495M0-
Total Cash303M527M57%
Total Debt217M0-
FUNDAMENTALS RATINGS
AXSM vs SYRE: Fundamental Ratings
AXSM
SYRE
OUTLOOK RATING
1..100
5050
VALUATION
overvalued / fair valued / undervalued
1..100
87
Overvalued
69
Overvalued
PROFIT vs RISK RATING
1..100
37100
SMR RATING
1..100
10097
PRICE GROWTH RATING
1..100
3936
P/E GROWTH RATING
1..100
10074
SEASONALITY SCORE
1..100
50n/a

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

SYRE's Valuation (69) in the Pharmaceuticals Major industry is in the same range as AXSM (87) in the Pharmaceuticals Other industry. This means that SYRE’s stock grew similarly to AXSM’s over the last 12 months.

AXSM's Profit vs Risk Rating (37) in the Pharmaceuticals Other industry is somewhat better than the same rating for SYRE (100) in the Pharmaceuticals Major industry. This means that AXSM’s stock grew somewhat faster than SYRE’s over the last 12 months.

SYRE's SMR Rating (97) in the Pharmaceuticals Major industry is in the same range as AXSM (100) in the Pharmaceuticals Other industry. This means that SYRE’s stock grew similarly to AXSM’s over the last 12 months.

SYRE's Price Growth Rating (36) in the Pharmaceuticals Major industry is in the same range as AXSM (39) in the Pharmaceuticals Other industry. This means that SYRE’s stock grew similarly to AXSM’s over the last 12 months.

SYRE's P/E Growth Rating (74) in the Pharmaceuticals Major industry is in the same range as AXSM (100) in the Pharmaceuticals Other industry. This means that SYRE’s stock grew similarly to AXSM’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
AXSMSYRE
RSI
ODDS (%)
Bearish Trend 6 days ago
90%
Bearish Trend 6 days ago
90%
Stochastic
ODDS (%)
N/A
Bearish Trend 6 days ago
88%
Momentum
ODDS (%)
N/A
Bullish Trend 6 days ago
87%
MACD
ODDS (%)
Bullish Trend 6 days ago
77%
Bullish Trend 6 days ago
80%
TrendWeek
ODDS (%)
Bullish Trend 6 days ago
79%
Bullish Trend 6 days ago
83%
TrendMonth
ODDS (%)
Bullish Trend 6 days ago
79%
Bullish Trend 6 days ago
83%
Advances
ODDS (%)
Bullish Trend 6 days ago
78%
Bullish Trend 6 days ago
85%
Declines
ODDS (%)
Bearish Trend 14 days ago
80%
Bearish Trend 28 days ago
90%
BollingerBands
ODDS (%)
Bearish Trend 6 days ago
82%
Bearish Trend 6 days ago
90%
Aroon
ODDS (%)
Bullish Trend 6 days ago
75%
Bullish Trend 6 days ago
82%
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AXSM
Daily Signal:
Gain/Loss:
SYRE
Daily Signal:
Gain/Loss:
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AXSM and

Correlation & Price change

A.I.dvisor indicates that over the last year, AXSM has been loosely correlated with XENE. These tickers have moved in lockstep 38% of the time. This A.I.-generated data suggests there is some statistical probability that if AXSM jumps, then XENE could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To AXSM
1D Price
Change %
AXSM100%
-4.74%
XENE - AXSM
38%
Loosely correlated
-1.45%
SYRE - AXSM
36%
Loosely correlated
-0.91%
AVBP - AXSM
36%
Loosely correlated
-7.79%
VANI - AXSM
36%
Loosely correlated
+1.13%
WVE - AXSM
36%
Loosely correlated
-5.67%
More

SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with APGE. These tickers have moved in lockstep 58% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then APGE could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
-0.91%
APGE - SYRE
58%
Loosely correlated
+0.20%
CGON - SYRE
58%
Loosely correlated
-4.35%
RGNX - SYRE
57%
Loosely correlated
-3.10%
IDYA - SYRE
57%
Loosely correlated
-1.75%
ORKA - SYRE
56%
Loosely correlated
+0.56%
More