APGE
Price
$78.09
Change
+$0.79 (+1.02%)
Updated
Dec 24 closing price
Capitalization
5.34B
75 days until earnings call
Intraday BUY SELL Signals
SYRE
Price
$33.05
Change
-$0.18 (-0.54%)
Updated
Dec 24 closing price
Capitalization
2.56B
63 days until earnings call
Intraday BUY SELL Signals
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APGE vs SYRE

Header iconAPGE vs SYRE Comparison
Open Charts APGE vs SYREBanner chart's image
Apogee Therapeutics
Price$78.09
Change+$0.79 (+1.02%)
Volume$465.15K
Capitalization5.34B
Spyre Therapeutics
Price$33.05
Change-$0.18 (-0.54%)
Volume$291.96K
Capitalization2.56B
APGE vs SYRE Comparison Chart in %
APGE
Daily Signal:
Gain/Loss:
SYRE
Daily Signal:
Gain/Loss:
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VS
APGE vs. SYRE commentary
Dec 25, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is APGE is a Buy and SYRE is a Hold.

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COMPARISON
Comparison
Dec 25, 2025
Stock price -- (APGE: $78.09 vs. SYRE: $33.05)
Brand notoriety: APGE and SYRE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: APGE: 57% vs. SYRE: 37%
Market capitalization -- APGE: $5.34B vs. SYRE: $2.56B
APGE [@Biotechnology] is valued at $5.34B. SYRE’s [@Biotechnology] market capitalization is $2.56B. The market cap for tickers in the [@Biotechnology] industry ranges from $117.47B to $0. The average market capitalization across the [@Biotechnology] industry is $2.23B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

APGE’s FA Score shows that 0 FA rating(s) are green whileSYRE’s FA Score has 0 green FA rating(s).

  • APGE’s FA Score: 0 green, 5 red.
  • SYRE’s FA Score: 0 green, 5 red.
According to our system of comparison, APGE is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

APGE’s TA Score shows that 2 TA indicator(s) are bullish while SYRE’s TA Score has 2 bullish TA indicator(s).

  • APGE’s TA Score: 2 bullish, 5 bearish.
  • SYRE’s TA Score: 2 bullish, 6 bearish.
According to our system of comparison, APGE is a better buy in the short-term than SYRE.

Price Growth

APGE (@Biotechnology) experienced а +3.43% price change this week, while SYRE (@Biotechnology) price change was -0.03% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +2.88%. For the same industry, the average monthly price growth was +4.46%, and the average quarterly price growth was +55.39%.

Reported Earning Dates

APGE is expected to report earnings on Mar 10, 2026.

SYRE is expected to report earnings on Feb 26, 2026.

Industries' Descriptions

@Biotechnology (+2.88% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
APGE($5.34B) has a higher market cap than SYRE($2.56B). APGE YTD gains are higher at: 72.384 vs. SYRE (41.967). SYRE has higher annual earnings (EBITDA): -223.64M vs. APGE (-282.33M). APGE has more cash in the bank: 527M vs. SYRE (486M). SYRE has less debt than APGE: SYRE (0) vs APGE (9.85M). APGE (0) and SYRE (0) have equivalent revenues.
APGESYREAPGE / SYRE
Capitalization5.34B2.56B208%
EBITDA-282.33M-223.64M126%
Gain YTD72.38441.967172%
P/E RatioN/A1.72-
Revenue00-
Total Cash527M486M108%
Total Debt9.85M0-
FUNDAMENTALS RATINGS
SYRE: Fundamental Ratings
SYRE
OUTLOOK RATING
1..100
64
VALUATION
overvalued / fair valued / undervalued
1..100
70
Overvalued
PROFIT vs RISK RATING
1..100
100
SMR RATING
1..100
97
PRICE GROWTH RATING
1..100
36
P/E GROWTH RATING
1..100
80
SEASONALITY SCORE
1..100
50

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

TECHNICAL ANALYSIS
Technical Analysis
APGESYRE
RSI
ODDS (%)
Bearish Trend 2 days ago
69%
Bearish Trend 2 days ago
90%
Stochastic
ODDS (%)
Bearish Trend 2 days ago
62%
Bearish Trend 2 days ago
90%
Momentum
ODDS (%)
N/A
Bearish Trend 2 days ago
84%
MACD
ODDS (%)
Bearish Trend 2 days ago
68%
Bearish Trend 2 days ago
89%
TrendWeek
ODDS (%)
Bullish Trend 2 days ago
85%
Bearish Trend 2 days ago
87%
TrendMonth
ODDS (%)
Bullish Trend 2 days ago
85%
Bullish Trend 2 days ago
83%
Advances
ODDS (%)
Bullish Trend 7 days ago
85%
Bullish Trend 8 days ago
85%
Declines
ODDS (%)
Bearish Trend 3 days ago
67%
Bearish Trend 2 days ago
90%
BollingerBands
ODDS (%)
Bearish Trend 2 days ago
80%
Bearish Trend 2 days ago
87%
Aroon
ODDS (%)
Bullish Trend 2 days ago
90%
Bullish Trend 2 days ago
84%
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APGE
Daily Signal:
Gain/Loss:
SYRE
Daily Signal:
Gain/Loss:
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APGE and

Correlation & Price change

A.I.dvisor indicates that over the last year, APGE has been loosely correlated with SYRE. These tickers have moved in lockstep 57% of the time. This A.I.-generated data suggests there is some statistical probability that if APGE jumps, then SYRE could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To APGE
1D Price
Change %
APGE100%
+1.02%
SYRE - APGE
57%
Loosely correlated
-0.54%
CLDX - APGE
52%
Loosely correlated
+0.94%
XNCR - APGE
52%
Loosely correlated
-0.13%
RGNX - APGE
50%
Loosely correlated
+0.77%
IRON - APGE
50%
Loosely correlated
+0.76%
More

SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with BEAM. These tickers have moved in lockstep 57% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then BEAM could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
-0.54%
BEAM - SYRE
57%
Loosely correlated
+1.33%
XNCR - SYRE
57%
Loosely correlated
-0.13%
RGNX - SYRE
57%
Loosely correlated
+0.77%
CGON - SYRE
56%
Loosely correlated
+0.22%
APGE - SYRE
56%
Loosely correlated
+1.02%
More