ALNY
Price
$465.37
Change
-$7.92 (-1.67%)
Updated
Dec 4, 04:59 PM (EDT)
Capitalization
62.53B
70 days until earnings call
Intraday BUY SELL Signals
IONS
Price
$81.81
Change
-$0.03 (-0.04%)
Updated
Dec 4, 04:59 PM (EDT)
Capitalization
13.26B
83 days until earnings call
Intraday BUY SELL Signals
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ALNY vs IONS

Header iconALNY vs IONS Comparison
Open Charts ALNY vs IONSBanner chart's image
Alnylam Pharmaceuticals
Price$465.37
Change-$7.92 (-1.67%)
Volume$20K
Capitalization62.53B
Ionis Pharmaceuticals
Price$81.81
Change-$0.03 (-0.04%)
Volume$44.92K
Capitalization13.26B
ALNY vs IONS Comparison Chart in %
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VS
ALNY vs. IONS commentary
Dec 05, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is ALNY is a StrongBuy and IONS is a Buy.

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COMPARISON
Comparison
Dec 05, 2025
Stock price -- (ALNY: $473.29 vs. IONS: $81.84)
Brand notoriety: ALNY and IONS are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: ALNY: 102% vs. IONS: 98%
Market capitalization -- ALNY: $62.53B vs. IONS: $13.26B
ALNY [@Biotechnology] is valued at $62.53B. IONS’s [@Biotechnology] market capitalization is $13.26B. The market cap for tickers in the [@Biotechnology] industry ranges from $117.5B to $0. The average market capitalization across the [@Biotechnology] industry is $2.2B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

ALNY’s FA Score shows that 1 FA rating(s) are green whileIONS’s FA Score has 0 green FA rating(s).

  • ALNY’s FA Score: 1 green, 4 red.
  • IONS’s FA Score: 0 green, 5 red.
According to our system of comparison, ALNY is a better buy in the long-term than IONS.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

ALNY’s TA Score shows that 7 TA indicator(s) are bullish while IONS’s TA Score has 4 bullish TA indicator(s).

  • ALNY’s TA Score: 7 bullish, 3 bearish.
  • IONS’s TA Score: 4 bullish, 4 bearish.
According to our system of comparison, ALNY is a better buy in the short-term than IONS.

Price Growth

ALNY (@Biotechnology) experienced а +6.33% price change this week, while IONS (@Biotechnology) price change was -1.04% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +1.21%. For the same industry, the average monthly price growth was +5.86%, and the average quarterly price growth was +56.03%.

Reported Earning Dates

ALNY is expected to report earnings on Feb 12, 2026.

IONS is expected to report earnings on Feb 25, 2026.

Industries' Descriptions

@Biotechnology (+1.21% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
ALNY($62.5B) has a higher market cap than IONS($13.3B). IONS YTD gains are higher at: 134.096 vs. ALNY (101.135). IONS (-170.69M) and ALNY (-170.84M) have comparable annual earnings (EBITDA) . ALNY has more cash in the bank: 2.86B vs. IONS (2.29B). ALNY has less debt than IONS: ALNY (1.3B) vs IONS (1.42B). ALNY has higher revenues than IONS: ALNY (2.46B) vs IONS (944M).
ALNYIONSALNY / IONS
Capitalization62.5B13.3B470%
EBITDA-170.84M-170.69M100%
Gain YTD101.135134.09675%
P/E Ratio1577.63N/A-
Revenue2.46B944M261%
Total Cash2.86B2.29B125%
Total Debt1.3B1.42B91%
FUNDAMENTALS RATINGS
ALNY vs IONS: Fundamental Ratings
ALNY
IONS
OUTLOOK RATING
1..100
7211
VALUATION
overvalued / fair valued / undervalued
1..100
100
Overvalued
100
Overvalued
PROFIT vs RISK RATING
1..100
850
SMR RATING
1..100
10097
PRICE GROWTH RATING
1..100
4136
P/E GROWTH RATING
1..100
3657
SEASONALITY SCORE
1..100
n/a50

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

ALNY's Valuation (100) in the Biotechnology industry is in the same range as IONS (100). This means that ALNY’s stock grew similarly to IONS’s over the last 12 months.

ALNY's Profit vs Risk Rating (8) in the Biotechnology industry is somewhat better than the same rating for IONS (50). This means that ALNY’s stock grew somewhat faster than IONS’s over the last 12 months.

IONS's SMR Rating (97) in the Biotechnology industry is in the same range as ALNY (100). This means that IONS’s stock grew similarly to ALNY’s over the last 12 months.

IONS's Price Growth Rating (36) in the Biotechnology industry is in the same range as ALNY (41). This means that IONS’s stock grew similarly to ALNY’s over the last 12 months.

ALNY's P/E Growth Rating (36) in the Biotechnology industry is in the same range as IONS (57). This means that ALNY’s stock grew similarly to IONS’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
ALNYIONS
RSI
ODDS (%)
Bullish Trend 2 days ago
72%
Bearish Trend 2 days ago
61%
Stochastic
ODDS (%)
Bearish Trend 2 days ago
75%
Bearish Trend 2 days ago
70%
Momentum
ODDS (%)
Bullish Trend 2 days ago
75%
Bullish Trend 2 days ago
66%
MACD
ODDS (%)
Bullish Trend 2 days ago
80%
Bullish Trend 2 days ago
77%
TrendWeek
ODDS (%)
Bullish Trend 2 days ago
72%
Bullish Trend 2 days ago
71%
TrendMonth
ODDS (%)
Bullish Trend 2 days ago
75%
Bullish Trend 2 days ago
73%
Advances
ODDS (%)
Bullish Trend 2 days ago
78%
Bullish Trend 7 days ago
67%
Declines
ODDS (%)
Bearish Trend 10 days ago
64%
Bearish Trend 15 days ago
66%
BollingerBands
ODDS (%)
Bullish Trend 2 days ago
79%
Bearish Trend 2 days ago
70%
Aroon
ODDS (%)
Bullish Trend 7 days ago
71%
Bullish Trend 2 days ago
73%
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ALNY
Daily Signal:
Gain/Loss:
IONS
Daily Signal:
Gain/Loss:
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ALNY and

Correlation & Price change

A.I.dvisor indicates that over the last year, ALNY has been loosely correlated with ARGX. These tickers have moved in lockstep 52% of the time. This A.I.-generated data suggests there is some statistical probability that if ALNY jumps, then ARGX could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To ALNY
1D Price
Change %
ALNY100%
+1.80%
ARGX - ALNY
52%
Loosely correlated
+0.70%
IONS - ALNY
42%
Loosely correlated
+0.65%
SGMO - ALNY
42%
Loosely correlated
+13.43%
INSM - ALNY
37%
Loosely correlated
+0.09%
ALLO - ALNY
37%
Loosely correlated
+13.43%
More

IONS and

Correlation & Price change

A.I.dvisor indicates that over the last year, IONS has been loosely correlated with CYTK. These tickers have moved in lockstep 63% of the time. This A.I.-generated data suggests there is some statistical probability that if IONS jumps, then CYTK could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To IONS
1D Price
Change %
IONS100%
+0.65%
CYTK - IONS
63%
Loosely correlated
+1.81%
MLYS - IONS
49%
Loosely correlated
+0.13%
IDYA - IONS
48%
Loosely correlated
+1.93%
MNKD - IONS
48%
Loosely correlated
N/A
RARE - IONS
46%
Loosely correlated
+8.90%
More